糖尿病预防试验（Diabetes prevention test）.doc

糖尿病预防试验（Diabetes prevention test） Diabetes prevention test Type 1 diabetes prevention trial Diabetes Prevention Trial - Type 1 Diabetes (DPT-1) [Objective] to determine whether early intervention with an antigen based treatment for non diabetic relatives of type 1 diabetes mellitus can delay the onset of type 1 diabetes mellitus * first-degree relatives of type 1 diabetes are more than 10 times more likely to develop diabetes than the general population * by detecting autoantibodies against the beta cell autoantigen of the pancreas, people with diabetes will be detected * the first step was screening for positive islet cell autoantibodies (ICA) * and then according to other indicators to determine the risk of type 1 diabetes, and intervention therapy Assess risk grade for diabetes mellitus Islet cell 1VGTT insulin develops within 5 years Dangerous autoantibody, first phase autoantibody, diabetes mellitus The possibility of secreting IAA by ICA In Height (+) disappears (+ - -) 50% Moderate (+) normal (+) 20~25% Low (+) normal (-) DPT-1 intervention trial 10 clinical centres, including more than 200 affiliated units, participated * experimental group: i.v. infusion of insulin per year Supplemented by long-term s/c injection of insulin * close observation group (control) * the experimental group received oral insulin * placebo control group DPT-1 implementation Screening 89220 first-degree relatives of type 1 diabetes 3152 patients with ICA (+) were identified 354 out of them were enrolled in the study 169 patients were randomly assigned to the insulin treatment group (injected or orally) 170 cases were randomly divided into observation group and control group Results: negative treatment failed to achieve obvious results * Note: ICA is not enough, GAD may be more important Oral insulin is slightly better than subcutaneous insulin injection American type 2 diabetes prevention program DPP-2 * multi center, 24 centers * large sample, 4000 cases of IGT, no obvious hear