Intermedin对脓毒症大鼠心脏功能的影响.docVIP

DOI: 10.16016/j.1000-5404.201410143 Intermedin对脓毒症大鼠心脏功能的影响朱娱吴跃田昆仑刘良明李涛（400042 重庆，第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室） [摘要目的 探讨Intermedin（IMD）对脓毒症大鼠心脏功能的影响。方法 采用盲肠结扎穿孔术（CLP）复制大鼠脓毒症模型，CLP+常规治疗、CLP+IMD早期治疗组、CLP+治疗观察IMD后大鼠心脏功能心输出量、心脏指数、每搏指数、氧供、氧耗、血气及动物存活时间、存活率的。结果 与假手术组比较，脓毒症后大鼠的心脏功能明显降低；采用常规治疗（包括输液、抗感染以及使用血管活性药物），尽管可以提高动脉血压和中心静脉压，但大鼠的心脏功能无明显改善；可明显改善心脏功能组织氧供和氧耗明显升高与脓毒症大鼠相比，IMD后，升高了大鼠的平均存活时间达到h，72 h存活率为5/16）。结论 IMD对脓毒症大鼠的心脏功能有较好的治疗作用。 关键词IMD；脓毒症；大鼠；心脏功 [通信作者] 李 涛， E-mail： LT200132@163.com [优先出版] /kcms/detail/51.1095.R0831.008.html(2015-03-09) Effect of intermedin on cardiac function in sepsis rats Zhu Yu, Wu Yue, Tian Kunlun , Liu Liangming, Li Tao (State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China) [Abstract] Objective: To investigate the effect of intermedin (IMD) on cardiac function in sepsis rats. Methods: The rat sepsis model was established with cecal ligation and puncture (CLP). The rats were divided into 5 groups, namely, sham, CLP, CLP+conventional treatment (CT), CLP+CT+early injection of IMD (E-IMD) and CLP+CT+later injection of IMD (L-IMD). The effects of early or later administration of IMD on cardiac functions [cardiac output, cardiac index, stroke index), oxygen supply (DO2), oxygen consumption (VO2), blood gas], animal survival time, and survival rate were observed. Results: As compared with the sham group, the cardiac function (cardiac output, cardiac index, stroke index) were significantly decreased after sepsis. Conventional treatment (including fluids, anti-infection and vasoactive drugs) increased arterial blood pressure and central venous pressure, while had no effects on cardiac functions. Early or later administration of IMD significantly improved cardiac functions. Oxygen supply and oxygen consumption were declined after sepsis, but early and later administration of IMD significantly increa