信息熵理论在热毒宁口服制剂中金银花与栀子提取工艺优选中的应用_王仁杰.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 5 期 2015 年 3 月 ·683 · 信息熵理论在热毒宁口服制剂中金银花与栀子提取工艺优选中的应用 王仁杰 1, 2，李 淼 1, 2，闫 明 1, 2，杨素德 1, 2，王振中 1, 2，萧 伟 1, 2* 1. 江苏康缘药业股份有限公司，江苏 连云港 222001 2. 中药制药过程新技术国家重点实验室，江苏 连云港 222001 摘 要：目的 应用信息熵理论优选热毒宁口服制剂中金银花与栀子的提取工艺。方法 以绿原酸、栀子苷、木犀草苷提取 率及浸膏得率为综合评价指标，选取提取时间、加水量及提取次数为影响因素，采用信息熵赋权法确定各指标的客观权重， 实现对提取工艺的正交试验优选。结果 最佳提取工艺为 12 倍量水提取 3 次，每次 1 h。结论 信息熵理论可用于热毒宁口 服制剂中金银花与栀子提取工艺的优选。 关键词：信息熵；热毒宁口服制剂；金银花；栀子；提取工艺；综合评价 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2015)05 - 0683 - 05 DOI: 10.7501/j.issn.0253-2670.2015.05.012 Application of information entropy theory in optimization of extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation WANG Ren-jie1, 2, LI Miao1, 2, YAN Ming1, 2, YANG Su-de1, 2, WANG Zhen-zhong1, 2, XIAO Wei1, 2 1. Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China 2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China Abstract: Objective To optimize the extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation by information entropy theory. Methods With the contents of chlorogenic acid, gardenoside, luteoloside, and the yield of extract as comprehensive evaluation indexes, the extraction time, dosage of water, and extraction times were selected as factors, the weight of them was determined by information entropy theory, and the extraction technology was optimized by orthogonal test. Results Optimum extraction technology was: Reflux extraction for 3 times with 12 folds water, 1 h each time. Conclusion The information entropy theory could be used in optimizing the extraction technology for Reduning Oral Preparation. Key words: information entropy; Reduning Oral Preparation; Lonicerae Flos ; Gardeniae Fructus ; extraction technology