多西紫杉醇及顺铂联合化疗治疗非小细胞肺癌.docVIP

多西紫杉醇及顺铂联合化疗治疗非小细胞肺癌 　【关键词】 多西 摘要：目的：多西紫杉醇与顺铂联合化疗治疗非小细胞肺癌的疗效及副反应。方法：我院2002年10月至2004年2月确诊的Ⅲ～Ⅳ期非小细胞肺癌45例，分成治疗组25例（多西紫杉醇75mg/m2静脉滴注，d1，顺铂75mg/m2静脉滴注，d1，21d一周期）；对照组20例（盖诺25mg/m2，d1、d8，静脉滴注，顺铂80mg/m2，d1静脉滴注，21d一周期）。结果：治疗组总有效率72%，对照组总有效率40%,两组有显著性差异。静脉炎发生率对照组明显高于治疗组。结论：多西紫杉醇与顺铂联合化疗治疗非小细胞肺癌是安全有效的。 关键词：非小细胞肺癌；化疗；多西紫杉醇；顺铂 Chemotherapy with Docetaxel and Cisplatin in Non-small-cell Lung Cancer Abstract： Objective: The aim of the study was to observe the efficacy and side effect of docetaxel and cisplatin combination for patients with non-small-cell lung cancer.Method:From October 2002 to February 2004,45 patients with pathological diagnosis of stage Ⅲ/Ⅳ non-small-cell lung cancer were administered.The patients were divided into two groups(treatnent and control).The treatment group(25 cases) was treated by docetaxel and cisplatin at the dose of 75mg/m2/d on day 1 intravenously every 21 days. The control group (20 cases) was given navelbine 25mg/m2/d on day 1 and 8 and cisplatin 80mg/m2/ on day 1 intravenously every 21 days. Result:The overall responses for the treatment group and the control group were 72%and 40%,respectively, there were statistically significant difference between the two groups(P＜0.05). The peripheral phlebitis was more pronounced in control group(P＜0.05). Conclusions:Compared with the control group, the regimen of docetaxel and cisplatin was effective and safe for patients with non-small-cell lung cancer. Key words：Non-small-cell lung cancer;Chemotherapy;Docetaxel;Cisplatin 肺癌是临床上常见恶性肿瘤。近年发病率逐年增加，非小细胞肺癌以手术为主，术后辅助放化疗，可提高疗效延长生存期。但我地区肺癌病人，就诊时多属晚期，失去了手术时机。所以化疗在晚期非小细胞肺癌治疗中占有重要位置。目前对非小细胞肺癌缺乏公认的有效的标准化疗方案。我们选择了多西紫杉醇加顺铂方案联合化疗，现报告如下： 1材料与方法 1.1病例选择：45例均为我院2002年10月至2004年2月病理证实的Ⅲ～Ⅳ期非小细胞肺癌，KPS评分＞60分，治疗前后血常规，肝肾功能、心电图正常，有可测量的临床观察指标。化疗二周期评价疗效。 1.2一般资料：共45例、男25例、女20例，年龄35～79岁之间，腺癌20例，鳞癌25例均为Ⅲ～Ⅳ期，分为治疗组25例，对照组20例。 1.3治疗方法：治疗组：多西紫杉醇75mg/m2静脉滴注，d1，用药前1d开始口服地塞米松7.5mg/d，共3d，防止过敏及水肿发生；顺铂75mg/m2静脉滴注，d1，三周为一周期。对照组：盖诺25mg/m2,d1、8静脉滴注，顺铂80mg/m2,d1，三周为一周期。二组均用格拉斯琼止吐，同时保肝、水化、利