肺癌肉瘤及肺母细胞瘤临床分析及文献复习.docVIP

肺癌肉瘤及肺母细胞瘤临床分析及文献复习 　　　【摘要】　目的　探讨肺癌肉瘤与肺母细胞瘤的临床特点、诊断、治疗方法，以提高其诊断率。方法　回顾性地总结自1979年1月～1998年11月收住的肺癌肉瘤15例，肺母细胞瘤2例，并结合文献对其组织发生、临床表现、诊断及治疗方法进行分析。结果　肺癌肉瘤及肺母细胞瘤均为肺内罕见的恶性肿瘤，镜下均可见上皮及间质两种成分，但又有其不同之处，手术前很难确诊。肺癌肉瘤主要症状为咳嗽、咳痰、血丝痰等。X线示以周围型居多。病灶大小约在2～5 cm之间。病灶密度均匀，可见空洞，可为中心或偏心溶解，内壁不规则。病灶边缘清楚，有分叶，还可见肺门及纵隔淋巴结肿大。支气管镜检查可见肿物阻塞管腔，或支气管狭窄，活检可见鳞癌、腺癌及大细胞癌。痰中亦可查到癌细胞，故极易与肺癌相混淆。14例行手术治疗并确诊，1例经淋巴结活检证实为肺癌肉瘤。肺母细胞瘤表现为发热（2/2）、咯血（1/2），X线及CT表现为肺内肿块，密度不均匀，1例胸腔积液中查见恶性肿瘤细胞，无法确诊，行肺穿刺活检确诊。1例行肺叶切除术后病理确诊，全组术后随访15例（2例癌肉瘤失访），随访率88%。其中4例（包括1例肺母细胞瘤）随访时仍健在。癌肉瘤1年生存率为30%（3/10），2年生存率为20%（2/10），其中1例生存6年以上。另1例肺母细胞瘤仅生存3个月。结论　两种肿瘤常易误诊，且预后差，外科手术是其主要的诊断和治疗手段。 　　The clinical analysis and review of literature of pulmonary carcinosarcoma and blastoma 　　【Abstract】　Objective　To explore the clinical characteristics, diagnosis, treatment of pulmonary carcinosarcoma and blastoma. Methods　Summarizing retrospectively 15 cases of pulmonary carcinosarcoma and 2 cases of pulmonary blastoma from January 1979 to November 1998, and reviewing literature to analyse their histologic, clinical feature,diagnosis and treament. Results　Pulmonary carcinosarcoma and blastoma both were found to be rare malignant tumors, and both epithelial and mesenchymal elements can be seen under the microscopy with different characteristic features. It was hard to be diagnosed before operati on. The main symptoms of pulmonary carcinosarcoma were cough, expectoration, sometimes bloody phlegm. X-ray showed that peripheral type were most common, and 2～5 cm in size, well-distributed in density, some showed central or eccentric cavities whose wall was irregular. The margin of the focuses were clear, leafy, the distensive lymph nodes of hilum or mediastium could also be seen. Bronchoscopic examination revealed the bronchial cavity was obstructed by mass or became stricted. Local biopsy can found squamous, adenocarcinoma or large cell carcinoma, respectively. Malignant cell can also be found in sputum. So it was easy to be confused with lung cancer.14 cases of the ca