血尿酸水平及冠状动脉病变程度关系.docVIP

血尿酸水平及冠状动脉病变程度关系 　 作者：张利刚，张万荣，张俊，范华，郑嘉泉 【关键词】 冠状动脉病变；高尿酸血症；冠脉血管造影术 　　［摘要］ 目的 探讨血浆血尿酸水平与冠脉病变程度的关系。方法 选择51例疑诊为冠心病并进行冠状动脉造影检查的病例，根据冠状动脉造影结果分为冠心病组(冠脉造影阳性30例)和非冠心病组(冠脉造影正常21例)。其中冠心病组单支病变13例，双支病变10例，三支病变7例。2组同时检测血脂各成分进行比较，最后分析血尿酸与冠脉病变程度的关系。结果 冠心病病人在体重指数、TG、TC、LDL、HDL方面与对照组差异无显著性(P＞0.05)，冠心病合并高尿酸血症明显高于冠脉造影正常组(P＜0.05)，病变冠脉支数差异有显著性(P＜0.05)。结论 血尿酸水平与冠脉病变的严重程度是一致的，检测血尿酸水平有可能成为一项有价值的、能预测冠心病事件的常规检查方法。 　　［关键词］ 冠状动脉病变；高尿酸血症；冠脉血管造影术 　　Study of the correlation between plasma urea acid the severity of coronary artery lesions 　　［Abstract］ Objective To investigate the correlation between plasma urea acid and coronary artery lesions.Methods 51 patients were divided into the control group (n=21) and the coronary artery heart disease (CHD) group (n=30),which included single vessel lesion (n=13),double vessel lesions (n=10) and triple vessel lesions (n=7) according to coronary angiography.At the same time the lipid components were examined and the relationship between UA and coronary artery lesions were analysed.Results Compared with the control,the total cholesterol (TC),low density lipoprotein cholesterol (LDL),triglyceride (TG) and high density lipoprotein cholesterol (HDL) were no difference in the CHD group,(P＞0.05)there were significant difference in terms of plasma urea acid level between the CHD group and the control.The analysis showed that plasma urea acid were most directly correlated with the coronary artery lesions in the CHD group.Conclusion The result suggest the severity of coronary artery lesion correlated with plasma urea acid level,and plasma urea acid are indicators than other. 　　［Key words］ coronary lesion;urea acid;angiography,coronary 　　近年来多重危险因素在冠心病发病中的作用日益受到关注，我们通过冠脉造影观察冠脉的粥样硬化病变，结合患者的血脂、血糖、血压水平进行相关性分析，以探讨多重危险因素，尤其血尿酸代谢异常在冠心病发病中的临床意义。 　　1 对象与方法 　　1.1 研究对象 选择我院2005年以来冠脉造影患者51例，除外肥胖、肝肾功能异常、甲状腺疾病、周围动脉疾病及严重心功能不全者。其中确诊冠心病30例(诊断标准为冠脉造影证实一支以上主要血管狭窄＞50%)，其中男24例，女6例，年龄37～78岁，平均(61.76±9.76)岁；包括急性心肌梗死8例，陈旧性心肌梗死4例，不稳定型心绞痛9例，稳定型心绞痛8例。对照组(非冠心病)21例(经冠脉造影证实血管正常或狭窄＜50%，变异型心绞痛除外)