赖氨酸的发酵转化--20150814.pdf

生 物 工 程 学 报 李东霞 等/ 生物法合成戊二胺研究进展 161 Chinese Journal of Biotechnology /cjbcn February 25, 2014, 30(2): 161−174 DOI: 10.13345/j.cjb.130256 ©2014 Chin J Biotech, All rights reserved 综 述 李东霞，黎明，王洪鑫，王舒雅，路福平 300457 , , , . . , 2014, 30(2): 161−174. Li DX, Li M, Wang HX, et al. Progress in biosythesis of diaminopentane. Chin J Biotech, 2014, 30(2): 161−174. 摘 要: 随着经济快速发展，大气污染和全球变暖的趋势日益恶化。世界上每年消耗大量石化资源来源的聚 酰胺，戊二胺作为聚酰胺的重要组成单体，生物法合成戊二胺具有经济学和生态学双重意义。目前, 生物法合 成戊二胺的工程菌主要有谷氨酸棒状杆菌和大肠杆菌，文中从微生物中戊二胺的代谢、戊二胺合成途径的关键 酶和转运蛋白、戊二胺生产最佳代谢途径和戊二胺产量的预测、代谢工程研究进展等方面综述了生物法合成戊 二胺的最新研究现状和进展，并对其前景进行了展望。 : 戊二胺，谷氨酸棒状杆菌，大肠杆菌，赖氨酸脱羧酶，尸胺转运蛋白 Received: May 18, 2013; Accepted: August 20, 2013 Supported by: National Natural Science Foundation of China (No., Key Technology Research and Development Program of Tianjin, China (No. 11ZCKFSY00900), Tianjin Research Program of Application Foundation and Advanced Technology (No. 11JCYBJC09600), Changjiang Scholars and Innovative Research Team (No. IRT1166). Corresponding author: Ming Li. Tel: +86-22 Fax: +86-22 E-mail: liming09@ (No. , (No. 11ZCKFSY00900), (No. 11JCYBJC 09600), (No. IRT1166) 162 ISSN 1000-3061 CN 11-1998/Q Chin J Biotech February 25, 2014 Vol.30 No.2 Progress in biosythesis of diaminopentane Dongxia Li, Ming Li, Hongxin Wang, Shuya Wang, and Fuping Lu Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China Abstract: Air pollution