Prognostic significance of urokinase—type plasminogen activator and its receptor in patients with systemic inflammatory response syndrome.docVIP

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2017-09-19 发布于福建
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Prognostic significance of urokinase—type plasminogen activator and its receptor in patients with systemic inflammatory response syndrome.doc

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Prognostic significance of urokinase—type plasminogen activator and its receptor in patients with systemic inflammatory response syndrome

Prognostic significance of urokinase—type plasminogen activator and its receptor in patients with systemic inflammatory response syndrome BACKGROUND： This study aimed to determine the plasma levels of urokinase-type plasminogen activator （uPA）， urokinase-type plasminogen activator receptor （uPAR）， D-dimer， IL-6 and TNF-α， and observe the relations among uPA， uPAR， D-dimer， IL-6 and TNF-α in patients with systemic inflammatory response syndrome （SIRS）. METHODS： A prospective， clinical case-control study was conducted in patients with SIRS at age of more than 55 years old treated during 2008-2010 at Wuhan Central Hospital. Venous blood samples were collected by routine venipuncture. Eighty-five patients were divided into two groups according to diagnostic criteria of SIRS： SIRS patients from intensive care units （n=50）， and non-SIRS patients from medical wards （n=35）. Thirty healthy blood donors who visited the General Health Check-up Division at Wuhan Central Hospital served as controls. Excluded from the study were （1） those patients with pregnancy；（2） those with cancer；（3） those died after admission into the ICU in 7 days；（4） those received cardiopulmonary resuscitation；（5） those who had previous blood system diseases； and （6） those with SIRS before admission into the ICU. The levels of uPA， uPAR， D-D， IL-6 and TNF-α in blood were detected by commercial enzyme-linked immunosorbent assay （ELISA） kit. The data were analyzed using SPSS version 17.0 and expressed as mean ± standard. Student’s t test and the Mann-Whitney U test were used in the analysis. The relations of uPA， uPAR and D-dimer， IL-6 TNF-α levels were analyzed using Spearman’s rank-order correlation coefficient test. RESULTS： The plasma levels of uPA ， uPAR， D-dimer，IL-6 and TNF-α in the patients with SIRS were obviously higher than those in the non-SIRS patients and controls （P0.05）. The establishment of ROC curve was based on the levels of uPAR， D-dimer， IL-6 and TNF-α in 24 hours for the di