通痹止痛颗粒的抗炎镇痛作用（Antiinflammatory and analgesic effects of Tongbi Zhitong granule）.docVIP

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通痹止痛颗粒的抗炎镇痛作用（Antiinflammatory and analgesic effects of Tongbi Zhitong granule）.doc

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通痹止痛颗粒的抗炎镇痛作用（Antiinflammatory and analgesic effects of Tongbi Zhitong granule）

通痹止痛颗粒的抗炎镇痛作用（Antiinflammatory and analgesic effects of Tongbi Zhitong granule） Antiinflammatory and analgesic effects of Tongbi Zhitong granule Update Date: 2010-06-08 Click: Li Bo, Huang Zhibo Abstract: TongBiZhiTong granules of intragastric administration of 2.5g.kg-1, 1.25g.kg-1 and 0.625g.kg-1, Freunds of rats with adjuvant arthritis has obvious therapeutic effect (P 0.01); of cotton caused granulation tissue hyperplasia in rats, were significantly inhibited (P 0.01); induced acute inflammation in mice carrageenan induced by croton oil and the ear swelling were significantly inhibited (P 0.01). At the same time, 0.4% of glacial acetic acid induced writhing pain in mice also showed a strong analgesic effect. Keyword: @ Tong Tong Zhitong granule / pharmacology; arthritis; adjuvant / TCD therapy CLC number: R285.5; R593.21 document identifier number: A, article number: 1003-9783 (1999) 06-0356-02 TongBiZhiTong granules by Xuanju, epimedium, rhizoma corydalis and other drugs, with strong gluten, expelling wind and cold, dampness swelling, general paralysis analgesic efficacy. It is mainly used in the treatment of rheumatoid arthritis and rheumatoid arthritis. In order to evaluate the preclinical pharmacological effect, we selected the Freunds adjuvant arthritis and the animal model of acute and chronic nonspecific inflammation animal model, investigate the anti-inflammatory and analgesic effect of TongBiZhiTong granules. 1 experimental materials 1.1 experimental drugs given in animal TongBiZhiTong granules raw cream, brown viscous, provided by the Guangxi banzhou pharmaceutical group company number 950906, per gram of extract equivalent to crude drug 5.64g, 2.50g cream equivalent to 1 bags of TongBiZhiTong granules (15g), 4 DEG C and the refrigerator spare, before the experiment with distilled water to the desired concentration; Cortisone Acetate Injection, milky white suspension, by the ninth pharmaceutical factory of Shanghai, No. 940802, before the experiment