银屑病光疗和光化学疗法的研究进展（Advances in phototherapy and photochemical therapy for psoriasis）.docVIP

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银屑病光疗和光化学疗法的研究进展（Advances in phototherapy and photochemical therapy for psoriasis）.doc

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银屑病光疗和光化学疗法的研究进展（Advances in phototherapy and photochemical therapy for psoriasis）

银屑病光疗和光化学疗法的研究进展（Advances in phototherapy and photochemical therapy for psoriasis） Since 1925, Goeckerman will be used for the treatment of psoriasis with topical tar preparations and ultraviolet radiation, and ultraviolet light therapy has become more and more widely used in the treatment of psoriasis. In 1953, Ingram achieved good results in the treatment of psoriasis with UVB and UVB, which has been used for half a century. With the deep understanding of ultraviolet light, in 1970s, it was found that oral administration of psoralen combined with long wave ultraviolet (UVA) radiation photochemical therapy (PUVA) is more effective in the treatment of psoriasis. Since the late 1980s, there has been a narrow wave UVB 311-313nm wavelength, and recently 308nm excimer lasers, which have made unprecedented progress in the treatment of psoriasis with ultraviolet light. The recent progress of ultraviolet light therapy and photochemical therapy for psoriasis is summarized as follows. The mechanism of ultraviolet treatment of psoriasis UVB and UVA play a major role in the treatment of multiple skin diseases by modulating the skin immune system, [1]. UVB radiation can cause the nucleus DNA to form light polymers, inhibit the synthesis of DNA, and then inhibit the proliferation of epidermal cells DNA in psoriatic patients. UVB can increase the tumor suppressor gene product p53, p53, and control the cell cycle, thus UVB can play an important role in prolonging the circulating cycle of psoriatic patients. UVB or UVA after irradiation can induce keratinocytes to produce cytokines and inhibit the anti-inflammatory or immune neural polypeptide, prostaglandin and other media play a role in immune regulation, change the Langer Hans cells antigen presenting function. Walters [2] research shows that narrow-band UVB irradiation. The skin lesions of patients with psoriasis of interleukin -12mRNA and interferon gamma mRNA decreased obviously, at the beginning of narrowband UVB treatment w