阿克他利片（Actarit Tablets）.docVIP

阿克他利片（Actarit Tablets） Actarit Tablets manual [name of drug] Generic name: Actarit Tablets Name used before： Trade name: English Name: Actarit Tablets Chinese Pinyin: Aketali Pian This product is the main component of actarit, a chemical called 4-acetylaminophenylacetic acid. Its structural formula is: C10H11N03 193.20 [traits] This product is white or white like. [pharmacology and toxicology] The mechanism of this product is not clear. It may be related to the inhibition of IL-1, beta, IL-6, TNF- alpha and MMP-1 production in synovial cells of patients joints. The animal experiment results suggest that the product of rheumatoid arthritis animal models (type II collagen induced arthritis in mice and spontaneous autoimmune arthritis in NRL/Ipr mice) to control the development of arthritis, the product of the rheumatoid arthritis patients had improved, but no analgesic and anti-inflammatory effects. [pharmacokinetics] According to Japanese literature reports, a healthy adult male oral 100mg-800mg of the product, rapid absorption by the gastrointestinal tract, about 2 hour blood concentration reached the peak rate of 17 ~ 20% in blood plasma protein binding, the elimination half-life is about 1 hours, 24 hours after administration in almost 100% with the prototype drug excreted in the urine. [indications] Rheumatoid arthritis. [usage and dosage] Take orally with other anti-inflammatory and analgesic drugs. Take 0.1g (1 tablets) once a day, 3 times a day. [adverse effects] According to Japanese literature reports: (1) severe adverse reactions: Nephrotic syndrome: once nephrotic syndrome (unknown incidence), it should pay great attention to regular inspection and monitoring. Once abnormal occurs, withdrawal should be taken and appropriate measures should be taken. The interstitial pneumonia: there have been associated with fever, cough, dyspnea, chest X - abnormal interstitial pneumonia (less than 0.1%), so we should observe the patients symptoms, once the symptoms, the