天然产物和结肠癌的现状和未来.pdf

NIH Public Access Author Manuscript Drug Dev Res . Author manuscript; available in PMC 2009 November 1. N Published in final edited form as: I H Drug Dev Res . 2008 November 1; 69(7): 460–471. doi:10.1002/ddr.20276. - P A A u Natural products and colon cancer: current status and future t h o r prospects M a n 1 1,2 u Subapriya Rajamanickam and Rajesh Agarwal s c 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, r i p Denver, Colorado, USA t 2University of Colorado Cancer Center, University of Colorado Denver, Denver, Colorado, USA Abstract Carcinogenesis is a multistage process consisting of initiation, promotion and progression phases. Thus, the multistage sequence of events has many phases for prevention and intervention. N Chemoprevention, a novel approach for controlling cancer, involves the use of specific natural I H products or synthetic chemical agents to reverse, suppress or prevent premalignancy before the - P development of invasive cancer. Several natural products, such as, grains, nuts, cereals, spices, fruits, A vegetables, beverages, medicinal plants and herbs and their various phytochemical constituents A u including, phenolics, flavonoids, carotenoids, alkaloids, nitrogen containing as well as organosulfur t h compounds confer protective effects against wide range of cancers including colon cancer. Since o r diet has an important role in the etiology of colon cancer, dietary chemoprevention received atte