2010年 mds的诊断与治疗.pptVIP

Prognosis of cytogenetics:Good:normal, -Y, del(5q), del(20q) Poor--Complex karyotypes (≥3 abnormalities),-7/del(7q)] Intermediate:Other abnormalities lnternational Prognostic Scoring System (IPSS) for MDS Score 0 0.5 1 1.5 2 Blast in BM(%) 5 5-10 11-19 20-30* karyotype Good intermediate poor Cytopenias# 0-1 2-3 *This group is recognized as AML in the WHO classification. #Cytopenias:Haemoglobin 100g/L;ANC1.8xl09/L;Platelets 100xl09/L Prognosis and predictive factorsof MDS Risk category Overall score Median survival* 25% progression* Low 0 5.7 9.4 INT-1 0.5-1.0 3.5 3.3 INT-2 1.5-2.0 1.1 1.1