昆虫酚氧化酶原激活酶研究 - 应用昆虫学报.pdfVIP

Chinese Journal of Applied Entomology 2015, 52(2): 281288. DOI: 10.7679/j.issn.20951353.2015.030 昆虫酚氧化酶原激活酶研究* ** 陈晓宇 时 敏 陈学新 310058 摘 要 Prophenoloxidase activating proteinase PAP 关键词 The prophenoloxidase activating proteinase in insects ** CHEN Xiao-Yu SHI Min CHEN Xue-Xin (Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China) Abstract Prophenoloxidase activating proteinase (PAP) is a key proteinase in the process of activation of prophenoloxidase in several insect defense mechanisms. An immune challenge can induce proteins at the start of the prophenoloxidase activation cascade to activate the precursor of PAPs by proteolytic cleavage. The activated PAPs cause inactive prophenoloxidase to form active phenoloxidase (PO) and ultimately to produce toxic substances in order to kill foreign organisms, such as pathogens and parasites. This paper reviews the characteristics and structure of PAPs in insects, as well as their role in the prophenoloxidase-activating system, and discusses the regulation of PAPs in host insects by parasitoid wasps. Key words prophenoloxidase activating proteinase, prophenoloxidase-activating system, parasitoid wasp, insect immunity