IGF-1胰岛素抵抗与BPH的相关性研究-第三军医大学学报.DOC

IGF-1﹑胰岛素抵抗与前列腺体积的 相关性研究 田勇 李华 陈素芳(郑州大学附属第一医院老年内分泌科) 摘要：目的：探讨胰岛素样生长因子1（IGF-1）﹑胰岛素抵抗程度与前列腺体积的相关性。方法：收集我院老年病科BPH病人90例，根据下尿路症状（LUTS）、国际前列腺症状评分(IPSS)、前列腺特异性抗原（PSA）以及经腹超声前列腺体积测定分为实验组和对照组。收集这些患者的一般资料和生化特征。结果：与对照组相比，实验组的空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、低密度脂蛋白（LDL-L）水平较高，而IGF-1与高密度脂蛋白（HDL-L）水平较低。结论：IGF-1﹑胰岛素抵抗与前列腺增生的程度有关，是BPH发生发展的危险因素。 关键词：胰岛素样生长因子1；胰岛素抵抗；良性前列腺增生症 Correlation between insulin-like growth factor-1、insulin resistance and prostate volume The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 【Abstract】 objective To explore the relationship between the insulin-like growth factor-1(IGF-1)、insulin resistance and prostate volume. Methods ninety old patients with benign prostatic hyperplasia were divided into two groups according to lower urinary tract symptoms(LUTS)、International Prostate Symptoms Score(IPSS)、prostate specific antigen(PSA) and prostate volume which was measured by abdominal ultrasound:experimental group and control group,and common data and biochemical characteristics were collected. Results fasting blood glucose, fasting serum insulin,HOMA,and LDL-cholesterol were significantly higher and IGF-1,HDL-cholesterol were significantly lower in experimental group as compared to controls. Conclusions IGF-1 and insulin resistance were related to the level of the enlargement of prostate volume,which were also risk factors in the development of BPH. 【Key words】 insulin-like growth factor-1; insulin resistance; benign prostatic hyperplasia. Corresponding author: Li Hua, Tel E-mail:easyandsunny@163.com 良性前列腺增生症（BPH）是老年男性的常见疾病，目前认为它是一个多因素疾病，与年龄﹑饮食结构﹑生活方式﹑慢性炎症以及体内雌雄激素的平衡改变有关，大量研究已证实与其进展性相关的因素有年龄，血清前列腺特异性抗原和前列腺体积等。近来研究发现，BPH与内分泌及代谢疾病也有密切关系，常常与肥胖、高血压、冠心病、血脂血糖异常等疾病并存[1]。而IGF-1水平的异常也是冠心病、胰岛素抵抗、内分泌紊乱、肿瘤等疾病的病因或危险因素之一[9-11]。但IGF-1、胰岛素抵抗与BPH之间的关系少有报道，现本文对三者间的关系作一研究。 对象与方法 1.1 病例来源 2010年3月-8月间在郑大一附院老年病科就诊的老年BPH患者(年龄60-75岁)共90例。其中实验组52例:有下尿路症状且经IPSS评分为中重度症状并经直肠指诊或经腹超声确诊为BPH。对照组为38例没有下尿路症状或经IPSS评分仅为轻度症状，PSA＜4ug/L，前列腺体积＜25m