第四章 缩合反应(简单版).pdf

Condensation Reaction (intermolecular) intramolecular α− α− α− 1α−⎯ aldol condensation α− β−β− 1 α− O OH or H OH H O 2 RCH2 C R RCH2 C C C R β R R O -H2O RCH2 C C C R R R 2α− ⎯ Claisen-Schimidt O OH OH O ArCHO + RCH2 C R Ar CH CH C R R -H2O H O Ar C C C R R ⎯Mukaiyama Aldol Reaction ⎯Mukaiyama Aldol Reaction Lewis LewisTiCl BF SnCl 4 3 4 Sn(OTf) MgX Ln(OTf) TBAF 2 2 3 O H OLi TMSCl LDA/THF CH C C(CH ) C C 3 3 3 -78°C H C(CH ) 3 3 H OTMS PhCHO (CH ) C Ph C C TiCl4 3 3 H C(CH )