健康安全环保管理体系-高压环境下的工作暴露极限(英文).pdfVIP

Health and Safety Executive Contents Introduction 4 Summary 5 1 Background 7 2 General information on exposure 8 2.1 Occupational activities involving hyperbaric exposure 8 3 Extrapolation of OELs to take account of increased absolute pressure 10 3.1 Basic principles 10 3.1.1 Partial pressure 10 3.1.2 Pressure changes 11 3.2 Toxicological response to chemicals under hyperbaric conditions 11 3.2.1 Experimental data on the toxicokinetic behaviour of substances under hyperbaric conditions 12 3.2.2 Theoretical considerations 14 3.2.2.1 Systemic toxicity 14 3.2.2.2 Local toxicity 14 3.3 Summary and conclusions 15 4 Extrapolation of OELs to take account of increased exposure duration 16 4.1 Introduction 16 4.2 Adjustment of 8-hour TWA OEL 16 4.2.1 Mathematical models 16 4.2.2 Linear adjustment 17 4.3 Adjustment of IS-minute STEL OEL 18 5 Overall summary and conclusions 19 6 References 21 Appendix 22 Further information 23 Occupational exposure limits for hyperbaric conditions Page 3 of 23 Health and Safety Executive Introduction This Hazard Assessment Document has been published by the UK Health and Safety Executive (HSE) and is aimed at a technical audience. In Great Britain, substances which may cause harm to health are subject to the Control of Substances Hazardous to Health Regulations (COSHH) 1999. These Regulations require employers to prevent, or if this is not reasonably practical, adequately control employees’ exposure to hazardous substances. Hazard Assessment Document