茂钛配合物水解的研究手段综述与专论-化工进展.PDF

化 工 进 展 ·364 · CHEMICAL INDUSTRY AND ENGINEERING PROGRESS 2016 年第35 卷第2 期 综述与专论 茂钛配合物水解的研究手段 李淑云，冯书晓，章亚东 （郑州大学化工与能源学院，河南郑州 450001 ） 摘要：由于茂钛配合物的易水解性严重影响其催化活性，而且其水解特点与抗肿瘤活性紧密相关，因此需要采 1 用合适的检测手段来评价其水解行为。本文介绍了一系列检测茂钛配合物水解的研究手段——UV-Vis 、H NMR 、 X 射线晶体学、电位分析法、电导法、量子化学计算方法，分析了各种测试方法适用的范围及优缺点。提出这些 测试方法有助于研究茂钛配合物的水解动力学，能够促进茂钛配合物在医学及化工方面的研究与进展。 关键词：配合物；水解；紫外-可见分光光度测定法；核磁共振；X 射线晶体学；电化学；电解；计算化学 中图分类号：TQ 32 文献标志码：A 文章编号：1000 –6613 （2016 ）02 –0364 –05 DOI ：10.16085/j.issn.1000-6613.2016.02.004 Methods to study titanium complexes hydrolysis LI Shuyun ，FENG Shuxiao ，ZHANG Yadong （College of Chemical and Energy，Zhengzhou University ，Zhengzhou 450001 ，Henan ，China ） Abstract ：The hydrolysis of titanium complexes has seriously limited their applications. Their hydrolytic characteristic was closely related to the antitumor activity. Therefore ，it was necessary to use proper testing methods to evaluate the hydrolytic behavior of titanium complexes. This article introduced a series of methods for investigating the hydrolysis of titanium complexes ，including 1 UV-Vis ，H NMR ，X-ray crystallography ，potentiometric analysis ，conductivity method，and quantum chemistry computations. The strength and shortcomings of those methods were analyzed and compared. It was also described that the methods contributed to the investigations on the hydrolytic kinetic of titanium complexes ，which could promote the progress of titanium complexes on medical and chemical industry. Key words ：compl