锥形线束CT功能成像模型研究.DOCVIP

基于投影数据的锥形线束CT功能成像 钱 鹰, 周 强, 韦庆杰 （400065 重庆，重庆邮电大学） [摘要] 目的 建立计算机仿真系统，研究基于投影数据的锥形线束CT功能成像的方法，实现在线功能图像引导的放疗（BIGRT）技术。 方法 使用常规CT对大白兔施动态增强扫描（DEC-CT），利用扇形束CT到锥形束CT的数据转换构建锥形束CT扫描的仿真系统，获得锥形束下的投影数据；对扫描对象的体素进行动态增强建模，基于获得的投影数据集，经最优化拟合求得各体素模型的参数，利用成熟的fCT模型实现功能锥形线束CT成像。 结果 对比仿真系统获得的锥形线束CT下各体素的时间密度曲线（TDC）和原DEC-CT获得的对应体素的TDC，发现在对比剂首次通过时的上升沿有较好吻合，在循环进入平衡后差异较大。 结论 基于投影数据可实现锥形线束CT功能成像，获得定量血流灌注值，其他功能参数值的获得还需进一步研究。 [关键词] 图像引导的放疗；锥形线束CT；功能成像 [中图法分类号] [文献标志码] A Functional Cone-beam CT Imaging Based on Projection Data Ying QIAN, Qiang ZHOU, Qingjie WEI (Chongqing University of Posts and Telecommunications, chongqing, 400065, China) [Abstract] Objective To build a computer simulation system for investigating functional cone-beam CT imaging based on projection data to realize on-line Biologic Image Guided Radiation Therapy. Methods Dynamic Enhancement CT scan are performed on rabbit. Computer simulation system is built and the cone-beam CT projection data are obtained by using the program of transferring the fan-beam data to the cone-beam data. The change of time-density of each voxel is modeled as a uniform function. Parameters of this function are resolved by using curve fitting based on the projection data. Finally, functional parameters of rabbit are computed by using existent fCT model. Results Comparing the Time-Density Curve from cone-beam CT data in simulation system and the Time-Density Curve at the same pixel from the original DEC-CT data, good fitting are found at the first increase of TDC and fault fitting are found at the other parts of TDC. Conclusion The functional cone-beam imaging can be implemented and quantified the perfusion by using projection data. Future investigation are necessary for other functional parameters. [Key words] IGRT, Cone-Beam CT, Functional Imaging 目前针对癌症的主要治疗手段有手术治疗、化学治疗（化疗）、放射治疗（放疗），其中放射治疗已成为癌症治疗中的最重要手段我国约有70%以上的癌症三维适形放疗（3DCRT）、调强放疗（IMRT）实现了静态三维靶区剂量分布的高度适形，较大程度上解决了靶区的剂量适形放射问题。等，其中PET技术是目前最为成熟的功能影像技术，但是其空间分辨率较低，