发育源性成人疾病.pdfVIP

国际生殖健康/计划生育杂志 2016年11月第35卷第6期 JIntReprodHealth蛐FamPlan，November2016熏 Vol.35熏 No.6 ·483 · ·综述· 邓冉冉，李洁，李增彦△ 【摘 要】 发育源性成人疾病是在“成人疾病的胎儿起源”这一假说的基础上发展而来，表明胎儿宫内 环境、新生儿、儿童期乃至人类生长发育的各个阶段所处的环境都会对成人疾病产生影响，其生物学基础有 发育的可塑性及“追赶生长”、基因机制、激素的编程等。发育源性成人疾病包括心血管疾病、2型糖尿病、多 囊卵巢综合征、炎症性和免疫性疾病等非感染性慢性疾病。本文就发育源性成人疾病的假说、生物学基础、 可能的疾病类型及其发育源性的相关研究进行阐述。 【关键词 】 发育源性成人疾病；婴儿，出生时低体重；心血管疾病；糖尿病，2型；多囊卵巢综合征；炎 症；免疫系统疾病 Developmental Origins of Adult Diseases DENG Ran-ran, LI Jie, LI Zeng-yan. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China 【Abstract 】 Developmental origins of adult disease, based on the concept of ＂fetal origins of adult disease, was used to demonstrate the effect of the fetus intrauterine environment and the developmental environment of newborn, childhood and adult on those adult diseases. The potential biological mechanism included the developmental plasticity, compensatory growth, genetic and epigenetics, hormonal adaptations, etc. Those non-infectious chronic diseases, such as cardiovascular disease, type 2 diabetes, PCOS, inflammatory and autoimmune diseases, are attributed to the developmental origins of adult disease. In this review, we discussed the hypothesis of developmental origins of adult disease, the biological basis and potential mechanism, the disease types, and its research progress. 【Keywords 】 Development origin of adult disease; Infant, low birth weight; Cardiovascular diseases; Diabetes mellitus, type 2; Polycystic ovary syndrome; Inflammation; Immune system diseases （Ｊ Ｉｎｔ Ｒｅｐｒｏｄ Ｈｅａｌｔｈ蛐Ｆａｍ Ｐｌａｎ ，2016 ，35 ：483-485 ） 近年来，大量流行病学数据、实验室研究、临床 说”的主要支持学说之一，已经被广泛接受并且应 研究证实胎儿、新生儿、儿童时期乃至人类生长发 用在医学的各个领域。FOAD假说最初由Baker和他 育各个阶段所处的环境都会对以后生命阶段的疾 的同事们提出，其研究发现20世纪早期英国婴儿死 病产生