炎性介质在SAP发病机制中的作用(有英文摘要).docVIP

炎性介质在重症急性胰腺炎发病机制中的作用 专业班级：2006级临床1班 姓名：丁冬 指导老师：高宁 炎性介质在重症急性胰腺炎(SAP)发病机制中的作用 专业：临床医学 姓名：丁冬 指导老师：高宁 摘 要： 重症急性胰腺炎是一种起病急、进展快、病情严重、病死率高的急腹症，其发病机制涉及的因素众多，关系复杂，目前尚未完全被阐明。许多科研人员仍致力于对其发病机制的研究，并不断取得了新的进展。近年来，对该病的研究主要集中在胰酶的自身消化、白细胞的过度激活、血液循环障碍和细菌感染等方面。在以上四方面的研究中，都涉及到各种炎性介质所起的作用，因此炎性介质的释放可视为重症急性胰腺炎病情失控的一个关键环节，对这一环节的深入探讨将有利于完善基础病理理论并指导临床治疗。本文主要阐述了几种炎性介质在重症急性胰腺炎发病机制中的作用。根据来自相关文献和实验模型所得出的数据与结论，可以肯定有多种炎性介质如TNF-α、IL-8等在重症急性胰腺炎的发病机制中具有重要的作用。现简述急性胰腺炎中参与全身炎症反应的主要炎性介质及其在重症急性胰腺炎发病机制中的作用。 关键词： 炎性介质, SAP，发病机制 The roles of inflammatory meditors in the pathogenesis of severe acutepancreatitis Major:clinical medicine Name:DongDing Instructor:NingGao ABSTRACT Severe acute pancreatitis (severe acutepancreatitis, SAP) is one kind of acute and fast progress and severe disease , its pathogenesis involves several factors, the complex relationship, at present are not entirely clear. Many researchers are still working on the pathogenesis of research, and constantly made new progress. In recent years, the research of the disease are mainly concentrated in pancreatic enzyme digestion, leucocytes of itself excessive activation, blood circulation barrier and bacterial infections, etc. In the above four sorts of study, involve various inflammatory mediators, therefore the role of inflammatory mediators release can be regarded as severe acute pancreatitis disease control is one of the key links in the depth of the links to perfecting basis pathological theory and guide clinical treatment. This article mainly elaborated several inflammatory mediators in severe acute pancreatitis pathogenesis in the role. According to the experimental models from relevant literatures and gains from data and conclusions, certainly have a variety of inflammatory mediators such as TNF-α, IL - 8, etc in severe acute pancreatitis pathogenesis of plays an important role. Now briefly introduce acute pancreatitis systemic inflammation in the main inflammatory mediators and in severe acute pancreatitis pathogenesis in th