硫自由基对炔酰胺、丁炔酮的选择性反应研究（Study on the selective reaction of sulfur free radical to alkyne amide and propargyl ketone）.pdfVIP

硫自由基对炔酰胺、丁炔酮的选择性反应研究 中文摘要 中文摘要 含硫有机化合物是一类非常重要的化合物。胱氨酸以及青霉素、头孢霉素等 含硫抗生素在医药中占有重要的地位，这些化合物在解除病痛、挽救生命中显示 出极大的应用前景。直到上世纪五十年代有机硫化学才真正成为有机化学的一个 重要分支，它提供了许多新的合成方法，并在染料、农药、医药、有机导电材料 以及各种高新技术产业中展现出广泛的应用前景，吸引了世界众多的科学家在该 领域进行不懈的研究。 本文分为三部分：第一部分介绍了醋酸锰（III ）引发的硫自由基对炔酰胺的 选择性加成环化反应，合成了新型的含硫氮杂螺环二酮类化合物；第二部分介绍 了在自然条件下，硫自由基对炔酰胺的选择性加成环化反应研究，合成了新型的 含硫螺环化合物；第三部分介绍了硫自由基对丁炔酮的选择性加成环化反应，成 功合成了新型的含硫螺环类化合物。 产物的结构经核磁共振谱、质谱等得到了证实，部分结构通过 X 单晶衍射证实。 关键词：醋酸锰、硫自由基、炔酰胺、炔酮 作 者：黄士钢 指导老师：邹建平 I 英文摘要 硫自由基对炔酰胺、丁炔酮的选择性反应研究 Study on the Regioselective Sulfur Radical Reactions to Unsaturated Systems Abstract Compounds containing sulfur are important, such as cystine, penicilin and cephamycin, they play an important role in our life. But the organosulfur chemistry truly became an important branch of organic chemistry is just trace back to 1950’s. It offers a lot of new synthetic methods and shows a broad of applied prospect in medicine, colourant, pesticide, organic conductive material and a variety of high-tech products. Scientists from all over the world are taking their untiring efforts to this field. This thesis contains three parts. Firstly, we described the addition of thiyl radicals to propynamides to afford the corresponding spirocyclohexadienone derivatives under the promotion of manganese(III) acetate. Secondly, we described the addition of thiyl radicals to propynamides to afford the corresponding spirocyclohexadienone derivatives in air. Lastly, we described the addition of thiyl r