血形态及血的发生.pptVIP

 1.?????? Components: ---formed elements: 45% red blood cell-erythrocyte white blood cell-leukocyte platelets  1) erythrocyte, red blood cell ---normal number: (4.2-5.5)X1012/L in male (3.5-5.0)X1012/L in female ABO blood type blood type antigen: A, B : -membrane protein hemolytic transfusion reaction -hemolysis→erythrocyte ghost * reticulocyte: immature cell remained ribosome: delicate network structure when stained with brilliant cresyl blue 0.5-1% of total erythrocyte population or 3-6% in neonate ---life span: 120 days 2) leukocyte ---a group of large cells with nucleus ---involve in defense and immune reaction ---normal number: (4.0-10) X109/L ---classification: granulocytes: /neutrophil /eosinophil /basophil agranulocytes: /lympocyte /monocyte ①???? neutrophil: 50-70% of total leukocyte population ---structure: LM: round, 10-12um in diameter rob-liked or poly morphous nucleus, 2-5 lobes fine neutrophilic granules-pink cytoplasm EM: specific granule: 80% small, 0.3-0.4 um ovoid or irregular in shape contain: lysozyme, phagocytin (defensin) , ect. azurophilic granule: 20% large, round or ovoid , 0.6-0.7 um electron dense acid phosphatase, peroxidase, ect. ---function: phagocytose bacterium: specific g.-kill B azurophilic g.- digest B ---life span: in blood 6-8 hours, in CT 2-3 days ②???? eosinophil: 0.5-3% of total leukocyte population LM: round,10-15 um in diameter 2 lobes nucleus rough bright red granules -acidophilic granules EM: granules: round or ovoid with cube-liked electron dense crystal contain: -ACPase -histaminase -peroxidase ③??? basophil: 0-1% of leukocyte population LM: less, round 10-12 um lobe, “S” shaped or irregular nucleus basophilic g.: contains heparin, histamine and acidophil chemotacti