原子力显微镜在生物领域中的应用-微生物所期刊联合编辑部.PDF

微生物学通报 APR 20, 2008, 35(4): 595~601 Microbiology © 2008 by Institute of Microbiology, CAS tongbao@ 专论与综述 原子力显微镜在生物领域中的应用 1* 2 3 1 1 2 张晓清 卜庆珍 裴晓琴 闫仲丽 降升平 孙 平 (1. 300457) (2. 300457 (3. 222005) 摘 要: 原子力显微镜(AFM)作为生物样品表面表征的有力工具, 具有独特的优势。本文在介绍原 子力显微镜基本原理的基础上, 综述了原子力显微镜样品制备以及原子力显微镜形貌分析、力曲 线以及动力学分析在生物领域中的应用。 关键词: 原子力显微镜(AFM), 原理, 样品制备, 应用 The Application of Atomic Force Microscope in Biological Field ZHANG Xiao-Qing1* BU Qing-Zhen2 PEI Xiao-Qin3 YAN Zhong-Li1 JIANG Sheng-Ping1 SUN Ping2 (1. Research Center for Modern Analysis Techniques, Tianjin University of Science Technology, Tianjin 300457) (2. College of Food Engineering and Biotechnology, Tianjin University of Science Technology, Tianjin 300457) (3. Department of Chemistry and Engineering, Huaihai Institute of Technology, Lianyungang 222005) Abstract: Atomic force microscope (AFM) has become a powerful tool for the characterization of bio-samples surfaces. In this paper, the working principles and methods of AFM were explained and the ap- plications of the sample preparation, image analysis, force curve and the dynamic analysis in the biological field were reviewed. Keywords: Atomic force microscopy (AFM), Principle, Sample preparation, Application Binning 1986 , (Atomic force microscopy, AFM), , AFM , , , [1] (OM)(EM) , AFM