基因 Chapter 23 Immune Diversity.pdf

Immune Diversity CHAPTER OUTLINE Introduction Recombination Generates Extensive Diversity Clonal Selection Amplifies Lymphocytes That Respond • A light chain locus can produce 1000 chains by combining to Individual Antigens 300 Vgenes with four to five Cgenes. • An H locus can produce 4000 chains by combining 300 • Each B lymphocyte expresses a single immunoglobulin and Vgenes, 20 Dsegments, and four J segments. each T lymphocyte expresses a single T cell receptor. Immune Recombination Uses Two Types of Consensus • There is a very large variety of immunoglobulins and T cell receptors. Sequence • Antfgen binding to an immunoglobulin or T cell receptor • The consensus sequence used for recombination is a hep­ triggers clonal multiplication of the cell. tamer separated by either 12 or 23 base pairs from a Immunoglobulin Genes Are Assembled from Their Parts nonamer. in Lymphocytes • Recombination occurs between two consensus sequences