Dairy consumption and risk of breast cancer：a meta-analysis of prospective cohort studies.pdf

Breast Cancer Res Treat (2011) 127:23–31 DOI 10.1007/s10549-011-1467-5 REVIEW Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies Jia-Yi Dong • Lijun Zhang • Ka He • Li-Qiang Qin Received: 10 February 2011 / Accepted: 17 March 2011 / Published online: 27 March 2011 Springer Science+Business Media, LLC. 2011 Abstract Epidemiologic findings are inconsistent regarding low-fat dairy intake than for high-fat dairy intake and for risk for breast cancer related to dairy consumption. We premenopausal women than for postmenopausal women. performed a meta-analysis of prospective cohort studies to There was a significant dose–response relationship of total examine the association between diary product consump- dairy food, but not milk, consumption with breast cancer tion and risk of breast cancer. A PubMed database search risk. Little evidence of publication bias was observed. In through January 2011 was performed for relevant studies. conclusion, findings of the present meta-analysis indicate We included prospective cohort studies that reported rela- that increased consumption of total dairy food, but not tive risks with 95% confidence intervals for the association milk, may be associated with a reduced risk of breast of dairy consumption and breast cancer risk. A random cancer. effects model was used to calculate the summary risk estimates. We identified 18 prospective cohort studies eli- Keywords Dairy products Milk Breast cancer gible for analysis, involving 24,187 cases and 1,063,471 Cohort studies Meta-analysis participants. The summary relative risk of breast cancer for the highest intake of total dairy food compared with the lowest was 0.85 (95% confidenc