异维a酸与直链淀粉包合物的制备及酶控释放动力学研究-药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 12, 47 (9): 1227 1230 ·1227 · 异维A 酸与直链淀粉包合物的制备及酶控释放动力学研究 1* 1 1 2 2 1 王齐放 , 李三鸣 , 张天弘 , 于 净 , 胡忠盛 , 李 岳 (沈阳 科大学 1. 学院, 2. 医疗器械学院, 辽宁 沈阳 1100 16) 摘要: 以直链淀粉为包合载体, 采用密封控温包合技术制备异维A 酸包合物, 通过粉末X-射线衍射及DSC 测试验证包合物的形成。运用动力学原理建立异维 A 酸/直链淀粉包合物的酶控释放动力学方程, 通过方程推 断在 -淀粉酶作用下 物释放的动力学规律。结果表明, 在无 -淀粉酶存在时, 物释放符合一级动力学模型; 当 -淀粉酶存在时, 物释放是由脱包和酶解共同作用的加速过程。预 异维A 酸/直链淀粉包合物可通过加入 -淀粉酶调控 物的释放。 关键词: 异维A 酸; 直链淀粉; 包合物; 物释放; 动力学 中图分类号: R943 文献标识码: A 文章编号: 05 13-4870 (20 12) 09- 1227-04 The preparation and kinetic study on enzymatically-controlled drug release of isotretinoin/amylose inclusion complex 1* 1 1 2 2 1 WANG Qi-fang , LI San-ming , ZHANG Tian-hong , YU Jing , HU Zhong-sheng , LI Yue (1. School of Pharmacy, 2. School of Medical Devices, Sheny ang Pharmaceutical University, Sheny ang 110016, China) Abstract: The inclusion complex of isotretinoin was prepared by sealed-control temperature method and amylose was used as carrier. The formation of inclusion complex was confirmed by powder X-ray diffraction and DSC. The equation of enzymatically-controlled drug release was established by kinetic theory, and the release characteristic of drug was confirmed by using the kinetic equation. The results show that the drug release was attributed to first order reaction without -amylase. However, with -amylase, the drug release was an acceleration p