磷酸川芎嗪星型聚乳酸缓释微球的制备与体外释放研究.pdfVIP

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磷酸川芎嗪星型聚乳酸缓释微球的制备与体外释放研究.pdf

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磷酸川芎嗪星型聚乳酸缓释微球的制备与体外释放研究

中草药 Chinese Traditional and Herbal Drugs 4 0 20 0 0 627 1 2 2* 林雅铃 , 张安强 , 王炼石 ( 1 , 510642; 2 , 510641) : , , L(sPLLA) , ( LP) ( sPLLA/ LP) , , sPLLA/LP , FTIR SEM sPLLA/ LP ,LP sPLLA , sPLLA/ LP 7 d , sPLLA sPLLA/ LP ,SEM , 0~ 48 h ; 48~ 144 h sPLLA/ LP : ; ;; :R28602 : A 2010) Preparation of sPLLA/ LP microspheres and its in vitro release properties 1 2 2 LIN aling , ZHANG Anqiang , WANG Lianshi ( 1 Department of Pharmaceutical Engineering, College of Resources and Environment, South China Agriculture University, Guangzhou 510642, China; 2 Department of Polymer M aterial Science and Engineering, College of M aterial Science and Engineering, South China University of Technology, Guangzhou 510641, China) Abstract: Objective To prepare starshaped poly ( Llactic acid) loaded ligustrazine phosphate (sPLLA/ LP) microspheres and study the influence of preparation technologies on drug encapsulation effi ciency of sPLLA/ Lp microspheres and its in vitro drug release Methods sPLLA/ LP Microspheres were prepared using themethod of solvent evaporation and W/ O/ W emulsion To optimize the preparation tech nology, an orthogonal design was applied FTIR and SEM were applied to characterize sPLLA/ LP micro spheres Results The optimized preparation technology was obtained based on range analysis and variance analysis LP could combine with sPLLA well, and part of sPLLA were degraded after 7 d inv itro relea