嗅鞘细胞移植治的疗脊髓损伤临床试验的初步报告.pdfVIP

18 海军总医院学报 2002 年第 15 卷第 1 期 临床研究 嗅鞘细胞移植治疗脊髓损伤临床试验的初步报告 黄红云 ,王洪美 ,修 　波 ,王 　锐 ,卢 　明 ,陈 　琳 ,亓树彬 陈 　林 ,张泽华 ,武海青 ,苟成青 ,程建铎 ,陆晓白 ,刘宗惠 (海军总医院神经外科 ,北京 100037) 　　摘要 : 目的 　开展嗅鞘细胞移植治疗脊髓损伤的临床试验 ,探讨其对脊髓损伤晚期患者是否有帮助脊髓 神经功能恢复的作用。方法 　取胚胎嗅球 ,消化成单个嗅鞘细胞后 ,培养 2～3 周 ,然后将其移植到脊髓损伤 部位的上下处。共治疗 23 例伤后时间为 05～85 年的脊髓损伤患者 ,其中 19 例为完全性脊髓损害 ,4 例为 不完全性脊髓损害。结果 　嗅鞘细胞移植后 2 周～2 个月时随访 ,23 例患者的脊髓功能均有改善 ,且呈继续 改善趋势。结论 　嗅鞘细胞移植能帮助脊髓损伤晚期患者的脊髓神经功能恢复。 关键词 :嗅鞘细胞 ;移植 ;治疗 ;脊髓损伤 ;临床试验 ( ) 中图分类号:R651. 2 　　文献标识码 :B 　　　文章编号 2002 Preliminary Report of Clinical Trial for Olfactory Ensheathing Cell Transplantation Treating the Spinal Cord Injury HUANG Hongyun , WANG Hongmei , XIU Bo , et al (Department of Neurosurgery , Naval General Hospital , Beijing 100037 , China) Abstract :Objective 　To develop clinical trial for olfactory ensheathins cells (OEC) transplantation treating the spinal cord injury , and to explore whether it would help the patients with spinal cord injury in late time to recover their spinal cord function. Methods 　Olfactory bulb was got and trypsinized to be single OECs ; which were cultured for 2～3 weeks , then transplanted OECs into the upper and lower sites between injury and normal spinal cord. 23 patients with the spinal cord injury were treated half year to eight and half years after injury. Among them 19 patients expressed complete spinal cord injury and other 4 with incomplete spinal cord injury. Results 　Followedup between 2 weeks and 2 months aft