左卡尼汀治疗老年冠心病心衰的疗同效观察.pdfVIP

中国现代医药杂志 年 月第 卷第 期 2010 1 12 1 MMJC, Jan 2010, Vol 12, No．1 - 55 - 左卡尼汀治疗老年冠心病心衰的疗效观察 陈冬梅 沈涛 李玉洁 石增刚 赵卓 【摘要】 目的 评价左卡尼汀 对冠心病慢性心力衰竭的治疗效果。方法 选择 例冠心病心衰患者，随机分 (L-CN) 80 为两组，每组 例：对照组予利尿剂、硝酸酯类药物、 受体阻滞剂、血管紧张素转化酶抑制剂或血管紧张素受体拮抗剂 40 β 治疗；治疗组在此基础上加用左卡尼汀 静点， 次 ，疗程 。 观察治疗前后心功能状况、左室射血分数、左室舒张 3.0g/d 1 /d 15d 末径及E/A 等心功能参数的变化，并观察药物不良反应。 结果 ①两组治疗后均有效；② 治疗组的总有效率高于对照组 （P0.05 ），心功能改善更为显著(P0.05) ，且未见不良反应。结论 冠心病心衰患者短期适量补充外源性左卡尼汀有益于改 善心功能。 【关键词】 冠心病 心力衰竭 左卡尼汀 疗效观察 Effects of L-carnitine on heart failure in the elderly patients with coronary heart disease Chen Dongmei,Shen Tao,Li ’ Yujie,et al.Department of Cardiology,The Third People s Hospital of Bengbu,Bengbu 233000 【Abstract 】 Objective To evaluate the effect of L-carnitine on heart failure in the elderly patiens with coronary heart disease. Methods Selected 80 patiens with heart failure, divided into two groups randomly.There were 40 patiens in each ， group. The control group were treated with diuretics angiotensin converting enzyme inhibitor or angiotensin receptor blocker, the therapy group were treated with conventional therapy and lcarnitine 3.0g/d for 15 days.The heart function and the side effects were observed. Results In the therapy group, the total effective rate was superior to the control group(P0.05),and the improve- ment of cardiac function was even more significant than the control group(P0.05),and no side-effect was observed. Conclusion Appropriate extraneous L-carnitine is probably beneficial to improve the cardiac function in the patients with heart failure and with