雷公藤的毒性机理及减毒方法研究进展_李并云鹃.pdfVIP

• 2612 • ( ) 中华中医药杂志 原中国医药学报 2017年6月第32卷第6期 CJTCMP , June 2017, Vol . 32, No.6 ·综述· 雷公藤的毒性机理及减毒方法研究进展 李云鹃，罗花，黄丽贞，谢滟，杜正彩，郝二伟，邓家刚 （广西中医药大学，南宁 530001） 摘要：雷公藤是一种有毒的中草药，临床上广泛用于治疗自身免疫系统疾病，其对于类风湿性关节炎疗效显 著，但由于其自身毒性所引起的消化系统、生殖系统和肾脏系统等一系列不良反应，使该药的使用受到了一定限 制。随着现代医药技术的发展，通过多种方法手段对雷公藤进行加工使其得到了较好的减毒效果，文章对有毒中 药雷公藤的毒性成分、致毒机理和减毒方法进行整理，以期能为该药物在临床的安全应用提供有益的参考。 关键词：雷公藤；毒性成分；毒性机理；减毒方法 基金资助：广西“八桂学者”工程专项经费资助（No.厅发[2013]3号），广西科技基础条件平台建设项目： 广西中药药效重点实验室（No.14-045-12） Advances in mechanism of toxicity and attenuated method of Tripterygium wilfordii LI Yun-juan, LUO Hua, HUANG Li-zhen, XIE Yan, DU Zheng-cai, HAO Er-wei, DENG Jia-gang ( Guangxi University of Chinese Medicine, Nanning 530001, China ) Abstract: Tripterygium wilfordii is a toxic Chinese herbal medicine, which has been widely used to treat autoimmune diseases in clinics and has significant effects on rheumatoid arthritis. But it usually be limited to use because its own toxicity caused a series of adverse reaction in digestive system, reproduction system and kidney system. With the development of modern technology, Tripterygium wilfordii get a better attenuation effect through various methods of processing. This paper collated the information about toxic components, mechanisms and methods about attenuating toxicity of Tripterygium wilfordii, which hopes to provide references for its widely using in the clinic. Key words: Tripterygium wilfordii; Toxic components; Toxic mechanism; Attenuated method Funding: Special Funds of ‘BaGui Scholars’ Construction Project (No.[2013]3), Project