女阴侵袭性血管粘液瘤的临床及病理特征.PDFVIP

现代妇产科进展 2004 年 9 月第 13 卷第 5 期 　Prog Obstet Gynecol ,Sep. 2004 ,Vol. 13 ,No. 5 ·论著· 女阴侵袭性血管粘液瘤的临床及病理特征 1 1 2 3 苏琴芬 ,王伟民 ,龙雯晴 ,张志钢 ( 1. 上海市闸北区中心医院妇产科 ,上海 　200070 ;2. 上海第二医科大学附属瑞金医院妇产科 ; 3. 上海医科大学病理学教研室) 　　【摘要】　目的 :研究女阴侵袭性血管粘液瘤的临床特点与病理特征 , 以免误诊漏诊。 方法 :对女阴侵袭性血管粘液瘤 2 例行手术切除 ,并行光镜和免疫组化检查。结果 :术中 见肿瘤呈无包膜生长 ,剖面苍白色、胶质样 ,有粘液性间质分隔。1 例因肿瘤浸润周围组 织 ,术后持续性反复出血 ,且于 5 月内复发。病检示瘤细胞呈梭形或星形排列于粘液样背 景中 ,核无异形性或分裂相 ,其间有中等以上厚壁血管。免疫组化染色示 Vimentin ( + ) 、 S100 ( - ) 。结论 :侵袭性血管粘液瘤罕见 ,侵袭性与复发性是其重要的临床特点。术前了 解肿瘤浸润范围十分必要。治疗以扩大的局部外阴切除为宜 ,并需长期随访。 【关键词】　血管粘液瘤 ;软组织肿瘤 ;病理学 ,临床;外阴 ;肿瘤复发 ,局部 ( ) 中图分类号:R737. 35 　文献标识码 :A 　文章编号 :1004 - 7379 2004 05 - 0356 - 03 Clinicopathological features of aggressive angiomyxoma of the vulva occuring in women. Su 1 1 2 Qinfen , Wang Weimin , Long Wenqing , et al . 1. Department of Obstetrics and Gynecology , Zhabei District Central Hospital , Shanghai 200070 ;2. Department of Obstetrics and Gynecology , Ruijin Hos pital , Shanghai Sencond Medical University 【Abstract 】　Objective :To study aggressive angiomyxoma of the vulva occuring in women as well as its clinical and pathological characteristics for avoiding misdignosis and missing diagnosis.Method :A detail clinical and pathological analysis was performed on two patients with aggressive angiomyxoma after operations. Results :Rowing with nonencapsulation , the tumour was segregated by myxoid stroma. The cut surface showed a soft ,gray white ,colloid. In the second case ,there was continuous hemorrhage repeatedly after operations in that tumors had infiltrated into peripheral tissue elapsing within five months. Histolog ically ,the tumour was composed of spindeshaped or stellatesha