肝癌干细胞标志物研究的进展.PDF

第 24 卷 第 1 期 中国普通外科杂志 Vol.24　No.1 2015 年 1 月 Chinese Journal of General Surgery Jan. 　2015 doi: 10.3978/j.issn. 1005-6947.2015.01.021 ·文献综述 · / 10.3978/j.issn. 1005-6947.2015.01.021 Chinese Journal of General Surgery, 2015, 24( 1): 110– 115. 肝癌干细胞标志物研究的进展 1 2 3 1 程康文 综述　詹勇强 ，王成友 ，王贵和 审校 （1. 安徽省铜陵市人民医院 普通外科，安徽 铜陵 244000；2. 广东省深圳市第二人民医院 肝胆外科，广东 深圳 518039； 3. 广东省深圳华侨医院 普通外科，广东 深圳 518111） 摘 要 肝癌是常见的恶性肿瘤，其目前的治疗手段是以手术为主的综合治疗，但是术后易复发、转移，预后较差。 肿瘤干细胞学说认为只有杀灭肝癌干细胞才能从根本上治愈肝癌，因此分离和鉴定肝癌干细胞成为研 究的热点。笔者就目前的肝癌干细胞表面标志物研究进展进行综述。 关键词 癌，肝细胞；肿瘤干细胞；分子标志物；综述文献 中图分类号：R735.7 Advances in research of liver cancer stem cell markers 1 2 3 1 CHENG Kangwen , ZHAN Yongqiang , WANG Chengyou , WANG Guihe (1. Department of General Surgery, Tongling People’s Hospital, Tongling, Anhui 244000, China; 2. Department of Hepatobiliary Surgery, Shenzhen Second People’s Hospital, Shenzhen, Guangdong 518039, China; 3. Department of General Surgery, Shenzhen Overseas Chinese Hospital, Shenzhen, Guangdong 518111, China) Abstract Liver cancer is a common malignancy, and its treatment strategy is mainly surgery-based comprehensive therapy, but the prognosis is still poor because of high frequency of postoperative recurrence and metastasis. According to the cancer stem cell theory, liver cancer can be radically cured only by eradication of the liver cancer stem cells, which leads to the isolation and identification of the liver cancer stem cells to become a hot area of research. This article overviews the r