欧米诺汗印法对糖尿病足溃疡发生风险的预测价值.pdfVIP

·560 · doi 10.3969/j.issn. 1673-4254.2014.04.26 J South Med Univ, 2014, 34(4): 560-562 临床研究 欧米诺欧米诺汗印法对糖尿病足溃疡发生风险的预测价值汗印法对糖尿病足溃疡发生风险的预测价值 覃 艳，曹 瑛，高 方，罗祥蓉，李际敏，符霞军，薛耀明 南方医科大学南方医院内分泌代谢科，广东 广州 510515 摘要：目的探讨欧米诺汗印法对糖尿病足溃疡（DFU）发生风险的预测价值。方法以振动觉阈值（VPT）作为评估DFU发生风 险的标准将725例2 型糖尿病（T2DM）患者分为DFU高危组和非高危组。利用受试者工作特征（ROC）曲线比较欧米诺汗印法 与10 g 尼龙单丝（10 g SWMF）检查对DFU发生风险的预测价值。结果725例T2DM患者中DFU高危组占6.1% ，该组患者的 年龄、DM病程、欧米诺颜色完全变化（CCC）时间及10 g SWMF 异常率均高于非高危组（P0.01）。ROC 曲线提示欧米诺CCC 时间对DFU发生风险的预测作用优于10 g SWMF ，前者ROC 曲线下面积约0.8，最佳切点为22.25 min。结论欧米诺汗印法能 有效预测DFU发生风险，在预防DFU 中具有重要应用价值。 关键词：欧米诺；泌汗功能；糖尿病足溃疡 Neuropad test for sudomotor function to predict the risk of diabetic foot ulceration QIN Yan, CAO Ying, GAO Fang, LUO Xiangrong, LI Jimin, FU Xiajun, XUE Yaoming Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Abstract: Objective To assess the predictive value of Neuropad test on occurrence of diabetic foot ulceration (DFU) among type 2 diabetic patients. Methods We divided 725 cases of type 2 diabetic patients into the high-risk and the non-high-risk groups of DFU based on the results of vibration perception thresholds(VPT) examination, which was widely used as a criteria for predicting DFU. Receiver operating characteristic (ROC) analysis was used to compare the effectiveness of Neuropad with 10 g Semmes-Weinstein monofilament (10 g SWMF) testing in predicting the risk of DFU. Results Among 725 patients of type 2 diabetes, 6.1% were at a high risk of DFU. Compared to non- high- risk group, patients in high- risk group had older age, longer diabetes duration, higher values of complete colour change time (CCC time) of Neuropad and higher abnormal rate of 10 g SWMF (P0.01). CCC time of Neuropad was shown to be better in predicting the risk of DFU than 10 g SWMF, and the area under the RO