MR医学影像文献Chen-2016-Chemical exchange saturation transfe.pdfVIP

Eur Radiol (2016) 26:1792– 1800 DOI 10.1007/s00330-015-3972-0 HEPATOBILIARY-PANCREAS Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla Shu-Zhong Chen 1 Jing Yuan 2 Min Deng 1 Juan Wei 3 Jinyuan Zhou 4,5 Yì-Xiáng J. Wáng 1 Received: 13 April 2015 /Revised: 4 August 2015 /Accepted: 6 August 2015 /Published online: 3 September 2015 # European Society of Radiology 2015 Abstract GlycoCEST measurements had 95 % limits of agreement of Purpose To evaluate Chemical Exchange Saturation Transfer −0.842 % to 0.899 % and −0.344 % to 0.164 %. After (CEST) MRI for liver imaging at 3.0-T. 24 hours, fasting rat liver APTw and GlycoCEST signals de- Materials and methods Images were acquired at offsets (n= creased from 2.38±0.86 % to 0.67±1.12 % and from 0.34± 41, increment=0.25 ppm) from −5 to 5 ppm using a TSE 0.26 % to −0.18±0.37 % respectively (p 0.05). After CCl4 sequence with a continuous rectangular saturation pulse. Am- intoxication rat liver APTw and GlycoCEST signals decreased ide proton transfer-weighted (APTw) and GlycoCEST signals from 2.46±0.48 % to 1.10±0.77 %, and from 0.34±0.23 % to were quantified as the asymmetric magnetization transfer ratio −0.16±0.51 % respectively (p 0.05). (MTRasym) at 3.5 ppm and the total MTRasym integrated from Conclusion CEST liver imaging at 3.0-T showed high sensi- 0.5 to 1.5 ppm, respectively, from the corrected Z-spectrum. tivity for fasting as well as CCl4 intoxication. Reproducibility was assessed for rats and humans. Eight rats Key Points were devoid of chow for 24 hours and scanned before and • CEST MRI of in-vivo liver was demonstrated at clinical 3 T after fasting. Eleven rats