MR医学影像文献Cai-2017-Effective tracking of bone mesenchyma.pdfVIP

Effective tracking of bone mesenchymal stem cells in vivo by magnetic resonance imaging using melanin-based gadolinium3 1 nanoparticles 1 1 2 3 2 1 Wen-Wen Cai, * Ling-Jie Wang, * Si-Jin Li, Xi-Ping Zhang, Ting-Ting- Li, Ying-Hua Wang, Xi Yang,1 Jun Xie,1 Jian-Ding Li,1 Shi-Jie Liu,1 Wen Xu,1 Sheng He,1 Zhen Cheng,4 Qu-Li Fan,5 Rui-Ping Zhang1 1Medical Imaging Department, First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China 2Molecular Imaging Precision Medical Collaborative Innovation Center, Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China 3Department of Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, 310022, China 4Molecular Imaging Program at Stanford Stanford University, Stanford, California 94305-5484 5Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing City, Jiangsu Province, 210023, China Received 27 June 2016; revised 12 August 2016; accepted 30 August 2016 Published online 21 September 2016 in Wiley Online Library (). DOI: 10.1002/jbm.a.35891 Abstract: Tracking transplanted stem cells is necessary to concentrations of less than 800 mg/mL. Furthermore, we clarify cellular properties and improve transplantation suc- tracked MNP-Gd31-labeled BMSCs in vivo using 3.0T MRI cess. In this study, we designed and synthesized melanin- equipment. After intramuscular injection, MNP-Gd31-labeled based gadolinium31 (Gd31)-chelate nanoparticles (MNP- BMSCs were detected, even after four weeks, by 3T MRI. Gd31) of 7 nm for stem cell tracking in vivo. MNP-Gd