MR医学影像文献Hu-2016-Superfluorinated copper sulfide nanopr.pdfVIP

Nano Research 2016, 9(6): 1630–1638 DOI 10.1007/s12274-016-1057-2 Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation Gaofei Hu, Juan Tang, Xilin Bai, Suying Xu, and Leyu Wang () State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China Received: 27 January 2016 ABSTRACT Revised: 21 February 2016 Copper sulfide (Cu S ) nanoparticles coated with an ultra-high payload (~5.0 × 107 7 4 Accepted: 22 February 2016 fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3,5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19F © Tsinghua University Press magnetic resonance (MR) signal and efficient near infrared photothermal and Springer-Verlag Berlin performance in water medium. In vivo assessment revealed strong 19F MR signals Heidelberg 2016 at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for KEYWORDS simultaneous 19F MR imaging and photothermal therapy. 19F magnetic resonance imaging, photothermal therapy 1 Introduction and therefore must be emulsified with organic carriers, such as micelles, liposomes, and other surfactants Owing to the extremely favorable nuclear magnetic for biological applications [1, 12, 14, 15]. Indeed, these resonance (NMR) properties