MR医学影像文献Ma-2016-Template-Free Synthesis of Hollow_Poro.pdfVIP

Research Article Template-Free Synthesis of Hollow/Porous Organosilica−Fe O 3 4 Hybrid Nanocapsules toward Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Therapy Ming Ma,† Fei Yan,‡ Minghua Yao,§ Zijun Wei,‡ Dongliang Zhou,‡ Heliang Yao,† Hairong Zheng,*,‡ Hangrong Chen,*,† and Jianlin Shi† †State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences,1295 Dingxi Road, Shanghai 200050, People’s Republic of China ‡Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, People’s Republic of China §Department of Ultrasound in Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchangzhong Road, Shanghai 200072, People’s Republic of China S *Supporting Information ABSTRACT: Entirely differing from the common templating- based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nano- capsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and unifor