MR医学影像文献Wang-2016-Detection of Alzheimers Disease by.pdfVIP

Journal of Alzheimer’s Disease 50 (2016) 233–248 233 DOI 10.3233/JAD-150848 IOS Press Detection of Alzheimer’s Disease by Three-Dimensional Displacement Field Estimation in Structural Magnetic Resonance Imaging Shuihua Wanga,b,c,1, Yudong Zhanga,c,∗,1, Ge Liud , Preetha Phillipse and Ti-Fei Yuana,∗ aSchool of Computer Science and Technology School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China b School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, China cJiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing, Jiangsu, China d Translational Imaging Division MRI Unit, Columbia University New York State Psychiatric Institute, NY, USA eSchool of Natural Sciences and Mathematics, Shepherd University, Shepherdstown, WV, USA Accepted 14 October 2015 Abstract. Background: Within the past decade, computer scientists have developed many methods using computer vision and machine learning techniques to detect Alzheimer’s disease (AD) in its early stages. Objective: However, some of these methods are unable to achieve excellent detection accuracy, and several other methods are unable to locate AD-related regions. Hence, our goal was to develop a novel AD brain detection method. Methods: In this study, our method was based on the three-dimensional (3D) displacement-field (DF) estimation between subjects in the healthy elder control group and AD group. The 3D-DF was treated with AD-related features. The three feature selection measures were used in the Bhattacharyya distance, Student’s t-test, and Welch’s t-test (WTT). Two non-parallel support vector machines, i.e., generalized eigenvalue proximal support vector machine and twin support vector machine (TSVM), were then used for classification. A 50 × 10-fold cross validation was implemented for statistical analysis. Results: The results showed that “