MR医学影像文献Xu-2016-Folic acid-conjugated GdPO4_Tb3+@SiO2.pdfVIP

J Nanopart Res (2016) 18: 334 DOI 10.1007/s11051-016-3649-x RESEARCH PAPER Folic acid-conjugated GdPO :Tb3+ @SiO Nanoprobe 4 2 for folate receptor-targeted optical and magnetic resonance bi-modal imaging Xianzhu Xu Xiaoying Zhang Yanli Wu Received: 28 August 2016 /Accepted: 26 October 2016 /Published online: 12 November 2016 # Springer Science+Business Media Dordrecht 2016 Abstract Both fluorescent and magnetic nanoprobes 5D4 → 7F5 transition of the Tb3+. The in vitro assays have great potential applications for diagnostics and with NCI-H460 lung cancer cells and human embryonic therapy. In the present work, a folic acid-conjugated kidney cell line 293T cells indicated that the and silica-modified GdPO :Tb3+ (GdPO :Tb3+ @SiO - GdPO :Tb3+ @SiO -FA nanoprobe could specifically 4 4 2 4 2 FA) dual nanoprobe was strategically designed and syn- bind the cells bearing folate receptors (FR). The MTT thesized for the targeted dual-modality optical and mag- assay of the NRs revealed that its cytotoxicity was very netic resonance (MR) imaging via a facile aqueous low. Further in vivo MRI experiments distinctively de- method. Their structural, optical, and magnetic proper- pict enhanced anatomical features in a xenograft tumor. ties were determined using transmission electron mi- These results suggest that the GdPO :Tb3+ @SiO -FA 4 2 croscopy (TEM), X-ray diffraction (XRD), Fourier NPs have excellent imaging and cell-targeting abi