MR医学影像文献Yang-2016-Postmortem Study of Validation of Lo.pdfVIP

Postmortem Study of Validation of Low Signal on Fat-Suppressed T1-Weighted Magnetic Resonance Imaging as Marker of Lipid Core in Middle Cerebral Artery Atherosclerosis Wen-Jie Yang, PhD; Xiang-Yan Chen, PhD; Hai-Lu Zhao, PhD; Chun-Bo Niu, MD; Bing Zhang, MD, PhD; Yun Xu, MD, PhD; Ka-Sing Wong, MD; Ho-Keung Ng, MD Background and Purpose—High signal on T1-weighted fat-suppressed images in middle cerebral artery plaques on ex vivo magnetic resonance imaging was verified to be intraplaque hemorrhage histologically. However, the underlying plaque component of low signal on T1-weighted fat-suppressed images (LST1) has never been explored. Based on our experience, we hypothesized that LST1 might indicate the presence of lipid core within intracranial plaques. Methods— 1.5 T magnetic resonance imaging was performed in the postmortem brains to scan the cross sections of bilateral D o w middle cerebral arteries. Then middle cerebral artery specimens were removed for histology processing. LST1 presence n l o was identified on magnetic resonance images, and lipid core areas were measured on the corresponding histology sections. a d e Results—Total 76 middle cerebral artery locations were included for analysis. LST1 showed a high specificity (96.9%; 95% d f r confidence interval, 82.0%–99.8%) but a low sensitivity (38.6%; 95% confidence interval, 24.7%–54.5%) for detecting o m lipid core of all areas. However, the sensitivity increased markedly (81.2%; 95% confidence interval, 53.7%–95.0%) h t t 2 p when only lipid cores of area ≥0.80 mm were in