MR医学影像文献Zhou-2016-Social behavioral testing and brain.pdfVIP

Zhou et al. BMC Neurosci DOI 10.1186/s12868-016-0266-7 BMC Neuroscience RESEARCH ARTICLE Open Access Social behavioral testing and brain magnetic resonance imaging in chicks exposed to mobile phone radiation during development 1*† 2† 1 1 1 1 1 Zien Zhou , Jiehui Shan , Jinyan Zu , Zengai Chen , Weiwei Ma , Lei Li and Jianrong Xu Abstract Background: The potential adverse efect of mobile phone radiation is currently an area of great concern in the ield of public health. In the present study, we aimed to investigate the efect of mobile phone radiation (900 MHz radi- ofrequency) during hatching on postnatal social behaviors in chicks, as well as the efect on brain size and structural maturity estimated using 3.0 T magnetic resonance imaging. At day 4 of incubation, 76 normally developing chick embryos were divided into the control group (n = 39) and the radiation group (n = 37). Eggs in the radiation group were exposed to mobile phone radiation for 10 h each day from day 4 to 19 of incubation. Behavioral tests were performed 4 days after hatching. T2-weighted MR imaging and difusion tensor imaging (DTI) were subsequently performed. The size of diferent brain subdivisions (telencephalon, optic lobe, brain stem, and cerebellum) and corre- sponding DTI parameters were measured. The Chi-square test and the student’s t test were used for statistical analysis. P 0.05 was considered statistically signiicant. Results: Compared with controls, chicks in the radiation group showed signiicantly slower aggregation responses (14.87 ± 10.06 vs. 7.48 ± 4.31 s, respectively; P 0.05), lower belongingness (23.71 ± 8.72 vs. 11.45 ± 6.53