MR医学影像文献Zhu-2016-Quantitative volumetric functional MR.pdfVIP

ª Springer Science+Business Media New York 2016 Abdom Radiol (2016) 41:1495–1504 Abdominal Published online: 10 March 2016 DOI: 10.1007/s00261-016-0694-y Radiology Quantitative volumetric functional MR imaging: an imaging biomarker of early treatment response in hypo-vascular liver metastasis patients after yttrium-90 transarterial radioembolization Xiangyu Zhu,1,2 Fatemeh Sobhani,2 Chunmiao Xu,2 Li Pan,3 Mounes Aliyari Ghasebeh,2 Ihab R. Kamel2 1The Shandong Medical Imaging Research Institute, Jinan 250021, Shandong, China 2The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe St., MRI 143, Baltimore, MD 21287, USA 3Siemens Healthcare, Baltimore, MD 21287, USA Abstract in volumetric ADC (37.2%; p = 0.01), decrease in arterial and venous enhancement (-58.5% and Purpose: To evaluate the value of quantitative volumet- -23.9%, respectively; p 0.001) at 1 month post-treat- ric functional MR imaging in early assessment of ment. Responding lesions did not change significantly by response to yttrium-90-labeled (90Y) transarterial anatomic metrics. radioembolization (TARE) in patients with hypo-vascu- Conclusions: RECIST, mRECIST, and EASL criteria lar liver metastases. failed to stratify lesions into responders and non- Materials and methods: Seventy four metastatic lesions in responders early after TARE in hypo-vascular liver 14 patients with hypo-vascular liver metastases after metastasis. Quantitative volumetric functional MR imag- TARE were included in this retrospective study. Diffu- ing could be a