小分子靶向抗肿瘤药物的研究进展-肿瘤药学.pdfVIP

- 168 - 肿瘤药学 2015 年 6 月第 5 卷第 3 期　Anti-tumor Pharmacy, June 2015, Vol. 5, No. 3 ●综　　述● 小分子靶向抗肿瘤药物的研究进展★ * 柏　静 ，杨长福 ，黄　 高，张明庆，方为民 （贵阳中医学院，贵州　贵阳，550002 ） 摘要：小分子靶向抗肿瘤药物是当前国内外创新药研发的热点，近些年来不断有新产品上市，还有数百个 产品正处于临床研发阶段。本文介绍了目前比较新颖和热门的抗肿瘤靶点，并列举了这些靶点比较有价值的 代表性药物。随着生命科学和药学的发展，今后必将发现更多、更有效的靶点和药效更好、毒性更小的化合物， 为肿瘤治疗提供新途径。 关键词：激酶抑制剂；靶向；小分子；抗肿瘤药物 中图分类号：R730.5 文献标识码 ：A 文章编号：2095-1264（2015）03-0168-06 doi：10.3969/j.issn.2095-1264.2015.034 Research Progress of Small-molecule Targeted Anti-tumor Drugs ★ * BAI Jing, YANG Changf u , H UANG Gao, ZHANG Mingqing, FANG Weimin (Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, 550002, China) Abstract: At present, the molecular targeted small-molecule anti-tumor drug becomes a hot topic of domestic and for- eign research and development of innovative drugs. There are always new products having been launched, and hundreds of products are in the clinical development stage in recent years. In this paper, we introduced some hot anti-tumor targets, and listed the representative drugs of these targets. With the development of bioscience and pharmacy, more and more effective targets will be found, and more effective but less toxic compounds will be produced to provide a new approach for the treat- ment of tumor in the future. Key words: Kinase inhibitor; Target; Small molecule; Anti-tumor drug 都提高了药物的选择性 ，而 c-Met 抑制剂 的研发却 前言 因没有找到适合 的适应症而屡屡受挫 。