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肝癌相关的生物信息学研究工作基础和专项研究思路
Bioinformatics in
Translational Medicine
Lu XIE (谢鹭)
Shanghai Center for Bioinformation Technology
(上海生物信息技术研究中心)
th
2014-06-19, The 12 Korean-Japan-China
Bioinformatics Training Course 2014, Jeju Island, Korea
谢鹭 (Lu Xie),Ph.D., M.D.
Translational Medicine Group, SCBIT
xielu@,
Training
– 1985-2000 Xiang Ya Medical College,
Central South University, M.D., Ph.D
-- 2000-2005 Vanderbilt University, USA, Postdoctoral Research Fellow
Career
– 1997-2000 Xiang Ya Medical College, Central South Univ, Assitant Prof.
– 2005-2009 Shanghai Center for Bioinformation Technolgoy, Assoc. Prof.
– 2010-now Shanghai Center for Bioinformation Technolgoy, Professor.
Research field
– Proteomics Bioinformatics: Proteogenomics, protein post-translational
modification, signaling transduction network
– Cancer Bioinformatics: tumor biomarker, clinical predictive models,
transcriptional regulatory network
Outline
Translational medicine definition
Why bioinformatics in translational medicine
Bioinformatics computational approaches
Bioinformatics applications in Translational
Medicine
Work cases
Translational medicine
Translational medicine is a discipline within
biomedical and public health research that
aims to improve the health of individuals and
the community by “translating ”findings
into diagnostic tools, medicines, procedures,
policies and education.
Wikipedia. Last updated on April 29, 2014
Traditional categorization
Basic research (fundamental or pure research) is
more speculative and takes a long time to be applied
in any practical context. Basic research often leads
to breakthroughs or paradigm-shifts in practice.
Applied research is research that can have an
impact in
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