钙依赖蛋白酶激活致中轴突神经丝退变.docVIP

Calcium-dependent proteasome activation is required for axonal neurofilament degradation* Joo Youn Park, So Young Jang, Yoon Kyung Shin, Duk Joon Suh, Hwan Tae Park Department of Physiology, Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, Busan, South Korea Abstract Even though many studies have identified roles of proteasomes in axonal degeneration, the molecular mechanisms by which axonal injury regulates proteasome activity are still unclear. In the present study, we found evidence indicating that extracellular calcium influx is an upstream regulator of proteas