汉族人endoglin基因多态性与颅内动脉瘤发病的-首都医科大学学报.pdfVIP

2006 2 F eb . 2006 27 1 Journal of Capit al U niversity of Medical Sciences Vol . 27 N o. 1 汉族人endoglin 基因多态性与颅内动脉瘤 发病的关系 1* 1 1 2 2 2 2 王江飞 张 东 赵继宗 陈保生 曾武威 李国平 毕 楠 ( 1. ; 2. ) ! endog lin 7 ( PCR) , PCR , ( PAGE) P CR 94 116 endog lin 7 endog lin 7 2 , ( 36 . 2% ) ( 12 . 1% ) ( = 8. 553, P = 0 . 005) 2 2 24 . 5% ( 4 6 188) , 6 . 03% ( 14 232) , , ( = 14. 409 , P= 0 . 000) endoglin ! endoglin ; ; ; ! R 739. 41 Study of the Relationship between the Polymorphism of the Endoglin Gene and Intracranial Aneurysm in Han Nationality 1* 1 1 2 2 2 2 Wang Jiangfei , Zhang Dong , Zhao Jizong , Chen Baosheng , Zeng Wuw ei , Li Guoping , Bi N an ( 1. Dep artment of Neurosurgery, Beij ing TiantanH osp ital, Cap ital University of Medical ciences; 2. Institute of Basic Medical ciences, Chinese A cademy of Medical cience and Peking Union Medical College) ABSTRA T! Objective T o study the relationship betw een the po lymorphism of the endoglin g ene and the incidence of intracranial aneurysm in the Han nationality. Methods T o compare t he allele g ene and genotype frequency of the insertion polymorphism around ex on 7 of the endo glin gene in 94 patients w ith intracr anial saccular aneur ysm s and 116 control volunteers by polymerase chain reaction ( PCR) , agarose gel electrophoresis, po lyacr ylamide gel( PAGE) electr ophoresis and direct sequencing. Results T he inser tion genotype