多发性内分泌腺瘤病演示稿.pptVIP

* This year marked the 20th anniversary of linking the MEN2 genetic defect to chromosome 10. Six years later two independent groups, Bruce Ponder at Cambridge and Helen Donis-Keller at WashU linked MEN2A to the RET proto-oncogene. The RET proto-oncogene encodes a trans-membrane receptor tyrosine kinase. * So what is RET? It is a type of receptor tyrosine kinase, just like c-kit and EGFR. The protein is mainly expressed in the neural crest and is essential for the development of enteric nervous system and kidney. Mutation of RET can either cause Hirshsprung disease or tumors, most importantly