磷酸钙微球骨修复材料研究进展-无机材料学报.pdfVIP

第29 卷 第 10 期 无 机 材 料 学 报 Vol. 29 No. 10 2014 年10 月 Journal of Inorganic Materials Oct., 2014 文章编号: 1000-324X(2014)10-1009-9 DOI: 10.15541/ji 磷酸钙微球骨修复材料研究进展 李 波, 徐文峰, 廖晓玲 (重庆科技学院 生物材料与活细胞影像技术研究所, 纳微复合材料与器件重庆市重点实验室, 重庆 401331) 摘 要: 磷酸钙微球具有良好的渗透性、高的比表面积、低致密度和较好的力学性能,在分离、催化、传感、组织工 程和药物释放等方面均有应用。本文综述了近年来磷酸钙陶瓷微球在组织工程和药物释放等骨修复相关领域的研 究进展, 介绍了实心、多孔、空心和花瓣状等四种不同结构磷酸钙陶瓷微球制备方法以及在骨修复领域中的应用, 并归纳总结了各类微球具有的优缺点和改进的方向, 为骨修复用磷酸钙微球的设计和制备提供较系统的参考。 关 键 词: 磷酸钙; 微球; 骨修复; 综述 中图分类号: R318 文献标识码: A Research Progress in Calcium Phosphate Microspheres for Bone Defect Repair LI Bo, XU Wen-Feng, LIAO Xiao-Ling (Institute of Biomaterials and Living Cell Imaging Technology, Chongqing Key Laboratory of Nano/Micro Composite Material and Device, Chongqing University of Science and Technology, Chongqing 401331, China) Abstract: Calcium phosphate ceramic microspheres have attracted many research interests in various application fields, such as separation, catalysis, sensor, tissue engineering and drug delivery, due to their excellent permeability, high surface area ratio, low density and stable mechanical properties. In this paper, current advances of calcium phos- phate ceramic microspheres in bone regeneration applications, such as bone tissue engineering and anabolic drug de- livery, were comprehensively reviewed. Calcium phosphate ceramic microspheres were classified into four main cate- gories according to their solid, porous, hollow or