应用64排CT评价两种剂量阿托伐他汀对急性冠脉综合征PCI术后冠状动脉斑块影响.docVIP

应用64排CT评价两种剂量阿托伐他汀对急性冠脉综合征PCI术后冠状动脉斑块影响 　　[摘要] 目的 通过64排CT观察两种不同剂量阿托伐他汀对血脂、超敏C反应蛋白（Hs-CRP）和冠状动脉斑块的影响。 方法 48例急性冠脉综合征（ACS）冠状动脉介入治疗（PCI）术后1个月内进行64排CT检查，随机分为强化他汀组（阿托伐他汀40 mg/d+常规用药）和常规他汀组（阿托伐他汀20 mg/d+常规用药），入组时分别检查TC、TG、LDL-C 、HDL-C、Hs-CRP和冠状动脉斑块类型及面积，随访12个月后再复查以上指标。 结果 治疗12个月后，两组TC、LDL-C、TG和Hs-CRP均较治疗前下降（P0.05）；两组脂质斑块和纤维斑块CT值均较前增加，强化他汀组更明显（P0.05）。 结论 应用64排CT可以定性、定量检查冠状动脉斑块情况；阿托伐他汀强化治疗可以使冠状动脉斑块更稳定，甚至缩小、逆转非钙化斑块。 [关键词] 64排螺旋CT；冠状动脉斑块；阿托伐他汀 [中图分类号] R543.3 [文献标识码] A [文章编号] 1674-4721（2013）07（a）-0026-03 Influence evaluation of two doses of Atorvastatin for coronary plaque of acute coronary syndrome after PCI by applying 64-slice CT MA Wen-xue PENG Jian-feng JIANG Zhi-gao GU Yu-yan BI Jian-cheng XV Zhi-qi Department of Cardiovascular Medicine， People’s Hospital of Huadu District in Guangzhou City of Guangdong Province， Guangzhou 510800， China [Abstract] Objective To observe the impact of two different doses of Atorvastatin on serum lipids， high-sensitivity C-reactive protein （Hs-CRP） and coronary plaque by 64-slice CT. Methods Forty eight patients with acute coronary syndrome （ACS）， who were detected by 64-slice CT within one month after percutaneous coronary intervention （PCI）， were randomly assigned into intensive statins group （Atorvastatin 40 mg/d + regular medication） and convention statins group （Atorvastatin 20 mg/d + regular medication） with TC， TG， LDL-C， HDL-C， hs-CRP， coronary plaque type and size examined simultaneously. The above indicators were reviewed after 12 months of follow up. Results After treatment of 12 months， the levels of TC， TG， LDL-C， and hs-CRP in both groups were lowered compare with the levels before treatment （P0.05）； the CT values of lipid and fibrous plaque area of patients in both groups were increased compared to the previous data with more significant change of intensive statins group （P0.05）. Conclusion Application of 64-slice CT can qualitatively and quantitatively detect changes of coronary plaque； intensive treatment of